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Working in conjunction with a teamfrom , the UT researchersz have determined the three-dimensional structure of a site on an influenzaw A virus protein that bind s to one of the huma n protein targets and consequently suppresses a person’sx natural defenses to infection. The so-called NSI viruzs protein is shared by all flu A viruses isolaterfrom humans, including avian flu, or bird flu, and the 1918 pandemicc influenza virus. "Our work uncovers an Achilles heel of influenza A virusee that cause human epidemicss and highmortality pandemics," says Rutgere Professor Gaetano Montelione, who is working with UT team leadet Professor Robert Krug.
"Wwe have identified the structure of a key target site for drugsd that could be develope d to effectively combat this A paper detailing the breakthrough discovery appearzs in the Proceedings ofthe . To see it clicki .
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